John E. Nestler, M.D.
The Virginia Chapter of the American College of Physicians honored John E. Nestler, M.D., with the 2013 Laureate Award at its Annual Meeting and Clinical Update held March 1-2 in Richmond. Nestler, who is the William Branch Porter Professor of Medicine and chair of Department of Internal Medicine, was honored for his distinguished service to the community and chapter.
He is a distinguished scholar and internationally recognized expert on the effects of insulin on polycystic ovary syndrome, a common condition related to diabetes, obesity and cardiovascular disease. In the 1980s, Nestler was among the first scientists in the world to suggest that insulin was an important reproductive hormone.
His pioneering work to induce ovulation through the use of such insulin-sensitizing drugs as metformin has led to the common use of metformin to treat infertility in women with PCOS, as well as to address their high risk for diabetes and cardiovascular disease. In a 1998 issue of the New England Journal of Medicine, Nestler’s research team was the first to publish findings of the combination therapy of metformin and clomiphene to promote ovulation.
He is the principal investigator on two National Institutes of Health grants, and his honors include the school of medicine’s Outstanding Research Achievement Award and Distinguished Mentor in Clinical Sciences Award. He has authored more than 100 original publications and edited three books.
Nestler, a graduate of the University of Pennsylvania’s School of Medicine, is a former chief medical resident at MCV Hospitals. He has served as chair of the department since 2009. He was vice chair from 2003 to 2009 and was chair of the Division of Endocrinology & Metabolism from 1997 to 2009.