Class of 2016’s Maximilian Jameson-Lee
On May 1, more than 40 students participated in the annual Medical Student Research Day.
This year’s Research Day saw a dramatic increase in the number of students presenting as a result of a change to poster session format. “In the past we had oral presentations and, because of limited time, only about 10 to 15 of the submitted abstracts were chosen for presentation,” said Gordon Archer, M.D., senior associate dean for research and research training in the School of Medicine. “This year the poster session format – and the poster printer purchased by our office – made it possible for everyone who did any summer research to present their work.”
Some of the presenters were past participants in the school’s Student Summer Research Fellowship Program, a two-month program between the M1 and M2 years in which students perform research under the guidance of a faculty member in the medical school. Other medical student presenters conducted research under the guidance of a medical school faculty mentor outside of the summer program.
Each year, three awards are given for the most outstanding presentations and research projects. The $1,000 first prize is made possible by the G. Watson James III, M.D. Scholarship Endowment that carries the name of a 1943 graduate of the medical school who went on to become Chairman of the Division of Hematology. At his death in 2001, James’ friends and family established the scholarship that goes to the medical student who wins the research competition, a fitting legacy for the outstanding physician-scientist. The second prize of $500 and $250 third prize are funded by the School of Medicine’s Dean’s Office.
Judges assessed the competition through various criteria in order to determine the top three presentations, including a coherent hypothesis, the presenter’s understanding of the background information of their research topic and the level of their participation in the experimental work. Finally, the judges scored the students based on the quality of their poster presentation and their ability to articulate findings and conclusions.
This year’s James Scholarship winner is the Class of 2016’s Maximilian Jameson-Lee. After earning a bachelor’s degree at the University of Florida, he went on to the National Institutes of Health to conduct infectious disease research. He then completed a Ph.D. in Immunology and Cancer from the University of Virginia and post-doctoral studies at Naval Research Labs in Washington D.C.
At Student Research Day, Max presented findings from a bone marrow transplant study that sought to refine the match between bone marrow donors and recipients for improved outcomes. Max explains that, today, bone marrow transplants are matched at 8 genetic locations and for blood type. For approximately the same price, whole exome sequencing looks at over 20,000 loci, which opens the door for a much more individualized approach. Less expensive than whole genome sequencing, exome sequencing analyzes just the coding regions of the genome.
Working in the research lab of Amir Toor, M.D., Max’s team performed whole exome sequencing on nine bone marrow donor/recipient pairs, searching for genetic differences. These differences could potentially cause the new immune system from the donor to recognize the recipient as foreign, thereby triggering an immune response that could produce adverse events such as graft vs. host disease. His research group found large differences on the genomic level but were not able to correlate those differences with transplant outcomes.
By Anish K. Desai