Single Molecule Analysis Group at VCU

Please visit our “Research” page for more details.

We combine DNA nanotechnology and modern analytical methods to achieve two major research goals; (i) develop multiplex sensors for biologically relevant small molecules such as biomarkers and (ii) investigate DNA mechanics in complex with protein(s). The research approach is interdisciplinary — it spans from DNA nanotechnology to single-molecule fluorescence microscopy, single-molecule force spectroscopy, and chemical biology. Our major areas of interest involve:

  • High-throughput sensing of biologically relevant targets
  • Protein-DNA mechanics
  • Single enzyme activity

We aim to accomplish following goals:

  • Develop multiplexed aptasensing platforms to ultimately benefit the areas of diagnostics and therapeutics
  • Illuminate how strained DNA molecules  interact with the DNA binding proteins at the molecular level
  • Investigate important kinetic parameters that are useful for understanding the behavior of single enzymes