Dr. Dhakal to present as a Keynote Speaker at the International Conference on Nanomaterials and Nanochemistry 2017 in Atlanta, Georgia (Nov 29-30, 2017) on the topic ‘From Material to Biotechnology Applications of Structural DNA Nanotechnology’.
Please visit our “Research” page for more details.
We combine DNA nanotechnology and modern analytical methods to achieve two major research goals; (i) develop multiplex sensors for biologically relevant small molecules such as biomarkers and (ii) investigate DNA mechanics in complex with protein(s). The research approach is interdisciplinary — it spans from DNA nanotechnology to single-molecule fluorescence microscopy, single-molecule force spectroscopy, and chemical biology. Our major areas of interest involve:
- High-throughput sensing of biologically relevant targets
- Protein-DNA mechanics
- Single enzyme activity
We aim to accomplish following goals:
- Develop multiplexed aptasensing platforms to ultimately benefit the areas of diagnostics and therapeutics
- Illuminate how strained DNA molecules interact with the DNA binding proteins at the molecular level
- Investigate important kinetic parameters that are useful for understanding the behavior of single enzymes