Dr. Dhakal to present as a Keynote Speaker at the International Conference on Nanomaterials and Nanochemistry 2017 in Atlanta, Georgia (Nov 29-30, 2017) on the topic ‘From Material to Biotechnology Applications of Structural DNA Nanotechnology’.
Please visit our “Research” page for more details.
We combine DNA nanotechnology and modern analytical methods to achieve two major research goals; (i) investigate protein-protein and protein-DNA mechanics at the single molecule level and (ii) develop multiplex sensors for biologically relevant small molecules such as biomarkers. The research approach is interdisciplinary — it spans from DNA nanotechnology to single-molecule fluorescence microscopy, single-molecule force spectroscopy, and chemical biology. Our major areas of interest involve:
- High-throughput sensing of small molecules, nucleic acids, and proteins
- Protein-protein and protein-DNA mechanics
- Single enzyme activity
We aim to accomplish following goals:
- Develop diverse/multiplexed biosensing platform to ultimately benefit the areas of chemical sensing, diagnostics, and therapeutics
- Investigate structural mechanisms of protein-protein interactions (PPIs) and study DNA modifying protein machineries at the molecular level
- Investigate the behavior of single enzymes